By Shannon Pacella, DPT, PHRC Lexington
First things first: if you haven’t already read the Part 1 to this post, please do so first!
There are a few updates since my first post regarding laws and legislature for marijuana (cannabis) use throughout the United States.
Updates
Currently, 29 states plus Washington, D.C. have legalized the use of medicinal marijuana, while nine of these states plus D.C. have legalized recreational marijuana use. Out of the remaining 21 states, 18 of them have legalized cannabidiol (CBD) which is considered to be non-psychoactive.1 Each state has their own specific parameters regarding the amount and form of marijuana that is allowed.
Almost every state has some degree of legalized use of marijuana (medicinal or cannabidiol use), which is pleasantly surprising especially since there has continued to be a lack of research being done. I was hoping by the time I got around to writing a part two, that I’d have loads of evidence based research to tout. Although I do not have hundreds (or evens tens) of research articles to delve into, the ones I am going to discuss do a good job of strengthening the relationship between medicinal marijuana use and treating pain.
In a review article by Hill and Palastro, chronic pain and neuropathic pain were two conditions with moderate to high quality evidence supporting the efficacy of medical cannabis pharmacotherapy.2 Animal pain models were used to demonstrate that the endocannabinoid system plays an active role in controlling pain; THC was shown to produce analgesic (pain relieving) and antihyperalgesic (decreased sensitivity to pain) effects in mice.2 Anecdotally, the pain relieving effects of THC has been supported by patients with chronic pain. Another review, demonstrated by multiple positive randomized placebo-controlled trials, determined that there was ‘high quality evidence’ to support the administration of cannabis or cannabinoid pharmacotherapy for treating neuropathic pain and chronic pain.2
“A recent report released by the National Academy of Science, Engineering, and Medicine in the United States stipulated that there was ‘conclusive or substantial evidence’ that cannabis or cannabinoids are effective treatments for chronic pain.”2
To further this connection, a systematic review and meta-analysis by Whiting, et al., 28 randomized clinical trials of cannabis and cannabinoid use for chronic pain, involving 2,454 participants was assessed.3 When compared with placebo, there was a higher reduction in pain measures with cannabinoids – the average number of patients who reported a reduction in pain of at least 30% was greater with cannabinoids than with placebo.3 Most of the studies reviewed suggested that cannabinoids were associated with improvements in chronic neuropathic pain, but these associations did not reach statistical significance in all of the studies.3
The final article I looked at discusses the clinical significance of endocannabinoids in endometriosis pain management. The endocannabinoid system (ECS) may serve as a pharmacological target for endometriosis treatments for pain management.4 The ECS is defined as a group of cannabinoid receptors located in the brain, central nervous system, and peripheral nervous system.4 The ECS is basically our body’s system that processes cannabinoids. There are two types of cannabinoid receptors: cannabinoid 1 (CB1) and cannabinoid 2 (CB2) receptors.4 Both CB1 and CB2 receptors are found within different membranes of the body: CB1 receptors are found primarily in the uterus, while CB2 receptors are found in the intestines, lungs, pancreas, and skin.4 Women with endometriosis have less CB1 receptors in endometrial tissue, leading some studies to describe endometriosis as an ‘endocannabinoid deficiency’.4
Analysis of clinical studies that focused on the relationship between ECS modulation and endometriosis-associated pain came up with some promising results:
- All of the studies showed a statistically significant improvement in chronic pelvic pain and dysmenorrhea (pain during menstruation).4
- The studies that specifically looked at dyspareunia (pain with sex) showed a significant improvement with the use of cannabinoids.4
- None of the studies analysed in the Whiting et al. article reported any adverse side effects.
I would be remiss not to mention the risks associated with cannabis use. Acute cannabis intoxication may lead to changes with perceptions of time and memory, as well as with motor functions.2 Cannabis may worsen existing anxiety or mood disorders, and it is also associated with the development of psychotic disorders in those with a genetic predisposition to these conditions.2 Other adverse effects of cannabis use may be: drowsiness, confusion, dizziness, fatigue, and disorientation.3 That being said, it is imperative that you speak with your primary care physician to discuss the option of medical marijuana/cannabis use.
Even though there have been strides made in the laws regarding medicinal marijuana/cannabis use, there needs to be a continued push to research the effects of this substance on more specific pain diagnoses, in order to have evidence based studies to back up these claims – to further improve how we treat complex pain conditions including chronic pelvic pain.
I am interested to hear your thoughts and opinions on medical marijuana – what do you think about it? Any personal experiences with using medical marijuana for pelvic pain? You are welcome to share below in the comments!
References:
- Should Marijuana Be a Medical Option? – Medical Marijuana – ProCon.org. Retrieved 9 March 2018, from https://medicalmarijuana.procon.org/
- Hill KP, Palastro MD. Medical cannabis for the treatment of chronic pain and other disorders: misconceptions and facts. Pol Arch Intern Med. 2017;127(11):785-789.
- Whiting PF, et al. Cannabinoids for medical use: A systematic review and meta-analysis. JAMA. 2015;313(24):2456-73.
- Bouaziz J, Bar On A, Seidman D, Soriano D. The clinical significance of endocannabinoids in endometriosis pain management. Cannabis Cannabinoid Res. 2017;2(1):72-80.
FAQ
What are pelvic floor muscles?
The pelvic floor muscles are a group of muscles that run from the coccyx to the pubic bone. They are part of the core, helping to support our entire body as well as providing support for the bowel, bladder and uterus. These muscles help us maintain bowel and bladder control and are involved in sexual pleasure and orgasm. The technical name of the pelvic floor muscles is the Levator Ani muscle group. The pudendal nerve, the levator ani nerve, and branches from the S2 – S4 nerve roots innervate the pelvic floor muscles. They are under voluntary and autonomic control, which is a unique feature only they possess compared to other muscle groups.
What is pelvic floor physical therapy?
Pelvic floor physical therapy is a specialized area of physical therapy. Currently, physical therapists need advanced post-graduate education to be able to help people with pelvic floor dysfunction because pelvic floor disorders are not yet being taught in standard physical therapy curricula. The Pelvic Health and Rehabilitation Center provides extensive training for our staff because we recognize the limitations of physical therapy education in this unique area.
What happens at pelvic floor therapy?
During an evaluation for pelvic floor dysfunction the physical therapist will take a detailed history. Following the history the physical therapist will leave the room to allow the patient to change and drape themselves. The physical therapist will return to the room and using gloved hands will perform an external and internal manual assessment of the pelvic floor and girdle muscles. The physical therapist will once again leave the room and allow the patient to dress. Following the manual examination there may also be an examination of strength, motor control, and overall biomechanics and neuromuscular control. The physical therapist will then communicate the findings to the patient and together with their patient they establish an assessment, short term and long term goals and a treatment plan. Typically people with pelvic floor dysfunction are seen one time per week for one hour for varying amounts of time based on the severity and chronicity of the disease. A home exercise program will be established and the physical therapist will help coordinate other providers on the treatment team. Typically patients are seen for 3 months to a year.
What is pudendal neuralgia and how is it treated?
Pudendal Neuralgia is a clinical diagnosis that means pain in the sensory distribution of the pudendal nerve. The pudendal nerve is a mixed nerve that exits the S2 – S4 sacral nerve roots, we have a right and left pudendal nerve and each side has three main trunks: the dorsal branch, the perineal branch, and the inferior rectal branch. The branches supply sensation to the clitoris/penis, labia/scrotum, perineum, anus, the distal ⅓ of the urethra and rectum, and the vulva and vestibule. The nerve branches also control the pelvic floor muscles. The pudendal nerve follows a tortuous path through the pelvic floor and girdle, leaving it vulnerable to compression and tension injuries at various points along its path.
Pudendal Neuralgia occurs when the nerve is unable to slide, glide and move normally and as a result, people experience pain in some or all of the above-mentioned areas. Pelvic floor physical therapy plays a crucial role in identifying the mechanical impairments that are affecting the nerve. The physical therapy treatment plan is designed to restore normal neural function. Patients with pudendal neuralgia require pelvic floor physical therapy and may also benefit from medical management that includes pharmaceuticals and procedures such as pudendal nerve blocks or botox injections.
What is interstitial cystitis and how is it treated?
Interstitial Cystitis is a clinical diagnosis characterized by irritative bladder symptoms such as urinary urgency, frequency, and hesitancy in the absence of infection. Research has shown the majority of patients who meet the clinical definition have pelvic floor dysfunction and myalgia. Therefore, the American Urologic Association recommends pelvic floor physical therapy as first-line treatment for Interstitial Cystitis. Patients will benefit from pelvic floor physical therapy and may also benefit from pharmacologic management or medical procedures such as bladder instillations.
Who is the Pelvic Health and Rehabilitation Team?
The Pelvic Health and Rehabilitation Center was founded by Elizabeth Akincilar and Stephanie Prendergast in 2006, they have been treating people with pelvic floor disorders since 2001. They were trained and mentored by a medical doctor and quickly became experts in treating pelvic floor disorders. They began creating courses and sharing their knowledge around the world. They expanded to 11 locations in the United States and developed a residency style training program for their employees with ongoing weekly mentoring. The physical therapists who work at PHRC have undergone more training than the majority of pelvic floor physical therapists and as a result offer efficient and high quality care.
How many years of experience do we have?
Stephanie and Liz have 24 years of experience and help each and every team member become an expert in the field through their training and mentoring program.
Why PHRC versus anyone else?
PHRC is unique because of the specific focus on pelvic floor disorders and the leadership at our company. We are constantly lecturing, teaching, and staying ahead of the curve with our connections to medical experts and emerging experts. As a result, we are able to efficiently and effectively help our patients restore their pelvic health.
Do we treat men for pelvic floor therapy?
The Pelvic Health and Rehabilitation Center is unique in that the Cofounders have always treated people of all genders and therefore have trained the team members and staff the same way. Many pelvic floor physical therapists focus solely on people with vulvas, this is not the case here.
Do I need pelvic floor therapy forever?
The majority of people with pelvic floor dysfunction will undergo pelvic floor physical therapy for a set amount of time based on their goals. Every 6 -8 weeks goals will be re-established based on the physical improvements and remaining physical impairments. Most patients will achieve their goals in 3 – 6 months. If there are complicating medical or untreated comorbidities some patients will be in therapy longer.
Comments
I like and agree with your article. Thanks for sharing
Hi Shannon! Thanks for sharing this post. I believe cannabis in regulated dose can be beneficial. Pelvic pain usually happens in women with dysmenorrhea and gynecologic disorders. Cannabis a miracle herb!